On Variance Estimation for the One-Sample Log-Rank Test

نویسندگان

چکیده

Time-to-event endpoints show an increasing popularity in phase II cancer trials. The standard statistical tool for such one-armed survival trials is the one-sample log-rank test. Its distributional properties are commonly derived large sample limit. It however known from literature, that asymptotical approximations suffer when size small. There have already been several attempts to address this problem. While some approaches do not allow easy power and calculations, others lack a clear theoretical motivation require further considerations. problem itself can partly be attributed dependence of compensated counting process its variance estimator. For purpose, we suggest estimator which uncorrelated process. Moreover, other present estimation covered as special cases by our general framework. practical application, provide calculations any approach fitting into Finally, use simulations real world data study empirical type I error performance methodology compared approaches.

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ژورنال

عنوان ژورنال: Statistics in Biopharmaceutical Research

سال: 2022

ISSN: ['1946-6315']

DOI: https://doi.org/10.1080/19466315.2022.2081600